Focal laser ablation

Focal laser ablation (sometimes described as MRI-guided laser interstitial thermal therapy or similar trade names) delivers laser energy into a planned region of the prostate while MRI provides real-time temperature feedback.

Mechanism

Laser fibre is placed perineally into the lesion or zone to be treated. MRI thermometry helps the operator stay within predefined temperature and volume limits relative to adjacent structures such as the urethra and neurovascular bundles.

Patient selection themes

Published cohorts usually restrict treatment to MRI-visible, biopsy-proven disease in men who accept close follow-up. The presence of high-volume or bilateral disease outside the target zone may argue for whole-gland strategies instead.

Outcomes and follow-up

Oncological and functional outcomes vary by series, technique generation and length of follow-up. Ask your team how they define treatment success, when repeat biopsy or imaging is planned, and what retreatment options remain.

Availability, device branding and regulatory status differ by country and hospital. This page does not state which laser platforms are offered at any specific centre.
References
  1. John R Heard, Aurash Naser-Tavakolian, Michael Nazmifar - Focal prostate cancer therapy in the era of multiparametric MRI: a review of options and outcomes - Prostate Cancer Prostatic Dis. 2023 Jun;26(2):218-227 - DOI: 10.1038/s41391-022-00501-0
  2. Le Nobin J, Rosenkrantz AB, Villers A, et al. - Image guided focal therapy for magnetic resonance imaging only visible prostate cancer: from conception to practice - Urology. 2017 Oct;108:8-15 - doi: 10.1016/j.urology.2017.05.039
  3. Nahar N, Peters B, van den Bos W, et al. - MRI-guided focal laser ablation for localized prostate cancer: a systematic review - J Magn Reson Imaging. 2021 Nov;54(5):1525-1537 - doi: 10.1002/jmri.27738

Considering focal therapy?

You can ask for a second opinion on imaging, diagnosis and treatment options before you decide.